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(VI) Autocrine Met-induced-activation is due to ectopic Met expression in cells yielding HGF, especially in acute myeloid leukemia ( The HGF/c-Met axis has an important role in cellular behaviors, such as cell proliferation, migration, survival, morphogenesis and the epithelialmesenchymal transition (EMT) ( The Hgf/c-Met Axis in Hcc Numerous in vivo and in vitro studies have demonstrated that HGF/c-Met play a critical role in the development of various human cancers (renal, lung, liver, breast, colon, thyroid, ovarian, and pancreas)

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